GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11825709 | 1 | rs57214110 | chr11:93668910 | HEPHL1 | chr11:93754378-93847374:+ | 0.43 | 3.86 | 0.000131 | Obesity-related traits |
| THCA | cis | rs12748152 | 1 | rs57217461 | chr1:27027916 | ZDHHC18 | chr1:27153201-27182207:+ | 0.8 | 8.35 | 7.37E-16 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs709400 | 1 | rs57218990 | chr14:104128007 | KLC1 | chr14:104029299-104167887:+ | -0.22 | -4.37 | 1.55E-5 | Body mass index |
| THCA | cis | rs16895812 | 1 | rs57228217 | chr6:42498342 | PRPH2 | chr6:42664334-42690358:- | -0.29 | -3.85 | 0.000135 | Obesity-related traits |
| THCA | cis | rs55883249 | 1 | rs57234614 | chr2:9756379 | IAH1 | chr2:9614670-9636671:+ | 0.16 | 3.53 | 0.000461 | 3-hydroxy-1-methylpropylmercapturic acid levels in smokers |
| THCA | cis | rs6885099 | 1 | rs57269846 | chr5:76529965 | PDE8B | chr5:76506706-76723226:+ | 0.11 | 3.55 | 0.000419 | Thyroid hormone levels |
| THCA | cis | rs2129782 | 1 | rs57283474 | chr8:89410289 | MMP16 | chr8:89049462-89339717:- | 0.31 | 5.04 | 6.5E-7 | Electrodermal activity |
| THCA | cis | rs726288 | 1 | rs57294261 | chr10:81729342 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs11871801 | 1 | rs57307201 | chr17:40572793 | NAGLU | chr17:40687951-40696464:+ | -0.23 | -4.91 | 1.23E-6 | Crohn's disease |
| THCA | cis | rs11871801 | 1 | rs57307201 | chr17:40572793 | TUBG2 | chr17:40811266-40819023:+ | -0.23 | -5.54 | 4.99E-8 | Crohn's disease |
| THCA | cis | rs7838490 | 1 | rs57311533 | chr8:89582889 | MMP16 | chr8:89049462-89339717:- | 0.16 | 3.69 | 0.000254 | Body mass index and cholesterol (psychopharmacological treatment) |
| THCA | cis | rs3740713 | 1 | rs57311859 | chr11:18454410 | LDHC | chr11:18433853-18472792:+ | -0.3 | -3.51 | 0.000484 | Amyotrophic lateral sclerosis (sporadic) |
| THCA | cis | rs2444240 | 1 | rs573211 | chr11:120044762 | TRIM29 | chr11:119981995-120008863:- | -0.14 | -3.38 | 0.000777 | Corneal curvature |
| THCA | cis | rs6988636 | 1 | rs57322232 | chr8:124193532 | FAM83A | chr8:124191287-124222317:+ | -0.29 | -3.98 | 7.99E-5 | Urinary uromodulin levels |
| THCA | cis | rs11825709 | 1 | rs57367718 | chr11:93668567 | HEPHL1 | chr11:93754378-93847374:+ | 0.47 | 4.13 | 4.27E-5 | Obesity-related traits |